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Oral Presentations

C1	Shared molecular regulatory mechanisms in embryonic valve development and osteogenesis Katherine Yutzey¹, Santanu Chakraborty¹, Jonathan Cheek¹, Christina Alfieri¹, ¹Cincinnati Children's Medical Center, United States
C2	Scleraxis is required for heart valve formation in vivo Agata Levay¹, Jacqueline Peacock¹, Karl Kadler², Robert Hinton³, Ronen Schweitzer⁴, Joy Lincoln¹, ¹University of Miami, United States,²University of Manchester, United Kingdom,³Cincinnati Children's Hospital, United States,⁴Portland Shriner's Research Center, United States
C3	Cadherin-11 is a potential mechanosensitive mediator of aortic valve formation and calcific degeneration Gretchen Mcaulliffe¹, Andrew Recknagel¹, Russell Norris², Jonathan Butcher^{1 1}Cornell University, United States,²Medical University of South Carolina, United States
C4	Phenotype of VICs from Normal and Pathological Pediatric Valves: Implications for a Tissue Engineered Heart Valve Elizabeth Stephens¹, Jennifer Shangkuan³, Kathleen Carberry², Debra Kearney², Charles Fraser², Jane Grande-Allen¹, ¹Rice University, United States,²Texas Childrens Hospital, United States,³University of California San Diego, United States
C5	Association between calcification of bicuspid aortic valve and notch1 mutations SA Mohamed¹, Z Aherrahrou², H Liptau², H Schunkert², HH Sievers¹, J Erdmann², ¹Cardiac Surgery, Germany,²MK II, Germany
C6	Mechanically-Regulated Differentiation of Valvular Interstitial Cells: Implications of Extracellular Matrix Remodelling in Aortic Valve Calcification Cindy Ying Yin Yip¹, Jan-Hung Chen¹, Craig A. Simmons¹, ¹University of Toronto, Canada
C7	Mechanical Strain of Aortic Valve Interstitial Cells Regulates TGF-β1 Activity Michael P. Nilo¹, Joanne E. Murphy-Ullrich¹, W. David Merryman¹, ¹University of Alabama at Birmingham, United States
C8	Bone morphogenic protein 4 regulates the shear stress-induced inflammatory pathway in aortic valve leaflets Philippe Sucosky¹, Adnan Elhammali¹, Kartik Balachandran¹, Hanjoong Jo², Ajit P. Yoganathan¹, ¹Georgia Institute of Technology, United States,²Emory University, United States
C9	Structural and Cellular Changes in Canine Myxomatous Mitral Valve Disease: An Image Analysis Study Richard I Han¹, Alex Black², Brendan M Corcoran¹, ¹University of Edinburgh, United Kingdom,²National University of Ireland, Ireland
C10	Finite Element Analysis of Pulmonary Autograft Dilation Peter Matthews¹, Ali Azadani¹, Brian Kim², Julius Guccione¹, Sloane Guy¹, Elaine Tseng¹, ¹University of California at San Francisco, United States,²University of California at Berkeley, United States
C11	Aortic Valve Mechanical Properties Are Regulated by the Cellular Components of the Valve Ismail El-Hamamsy¹, Kartik Balachandran², Padmini Sarathchandra¹, Patricia M. Taylor¹, Ajit P. Yoganathan², Magdi H. Yacoub¹, Adrian H. Chester¹, ¹Harefield Heart Science Center, Imperial College London, United Kingdom,²Geogia Institute of Technology, United States
C12	Dynamic In Vivo Deformation of the Mitral Valve Leaflet and Annulus In Synchrony Chad Eckert¹, Joesph Gorman², Michael Sacks¹, ¹University of Pittsburgh, United States,²University of Pennsylvania, United States
C13	Electrical Stimulation Stiffens Ovine Mitral Leaflets In Vivo Akinobu Itoh¹, Gaurav Krishnamurthy¹, Julia C. Swanson¹, Daniel B. Ennis¹, Wolfgang Bothe¹, George T. Daughters², D. Craig Miller¹, Neil B. Ingels², ¹Stanford University, United States,²Palo Alto Medical Foundation Research Institute, United States
C14	Using In Vitro Models of Valvular Disease to Study Anti-Calcific Therapies Elyssa Monzack¹, Kristyn Masters¹, ¹University of Wisconsin- Madison, United States
C15	Presence of Human Cathelicidin Antimicrobial Peptide LL-37 in the Calcific Aortic Valves Wen-fang Meng², Padmini Sarathchandra¹, Lucy Clark¹, Patricia Taylor¹, Magdi Yacoub¹, Adrian Chester¹, ¹Imperial College London, United States,²Zhejiang University School of Medicine, China
C16	Interstitial Aortic Valve Cells Subpopulations Exhibit Different Calcifying Potential When Exposed to Endotoxin and Phosphate Marcello Rattazzi¹, Laura Iop¹, Elisabetta Faggin¹, Giacomo Zoppellaro¹, Elisa Bertacco¹, Massimo Puato¹, Gino Gerosa¹, Saverio Sartore¹, Paolo Pauletto¹, ¹University of Padova, Italy
C17	High frequency of mesenchymal progenitors and osteoprogenitors in the porcine aortic valve Jan-Hung Chen¹, Cindy Ying Yin Yip¹, Eli D. Sone¹, Craig A. Simmons¹, ¹University of Toronto, Canada
C18	Hypoxia Induced Near-Native Mechanical Properties Of Engineered Heart Valve Tissue Carlijn Bouten¹, Angelique Balguid¹, Anita Mol¹, Frank Baaijens¹, ¹Department of Biomedical Engineering, Eindhoven University of technology, Netherlands
C19	In Vivo Tissue Engineering of Heart Valves Using High Specific DNA-Aptamers as Capture Molecules for Circulating Endothelial Progenitor Cells (EPCs) Martina Schleicher¹, Petra Kluger², Jan Hansmann², Hans-Peter Wendel¹, Olaf Fritze¹, Heike Mertsching², Gerhard Ziemer¹, Ulrich A. Stock¹, ¹Dept. of Thoracic, Cardiac and Vascular Surgery, University-Hospital Tuebingen, Germany,²Fraunhofer Institute for Interfacial Engineering and Biotechnology, Germany
C20	Fibrin-Based Tissue-Engineered Heart Valves: Results of a First In Vivo Evaluation Thomas Flanagan¹, Julia Frese¹, Jörg Sachweh², Nina Bernstein², Thomas Schmitz-Rode¹, Stefan Jockenhoevel¹, ¹Helmholtz Institute for Biomedical Engineering, Germany,²University Hospital Aachen, Germany
C21	Autologous Heart Valve Tissue Engineering: Repopulation Of Homograft-Derived Decellularized Matrices With Human Mesenchymal Stem Cells Laura Iop¹, Vera Renier¹, Filippo Naso¹, Alessandro Gandaglia¹, Antonella Bonetti², Fulvia Ortolani², Paolo De Coppi³, Maurizio Marchini², Michele Spina¹, Saverio Sartore¹, Gino Gerosa¹, ¹University of Padova, Italy,²University of Udine, Italy,³University College, United Kingdom
C22	3D In-vivo Geometric Characterization of the Right Ventricular Outflow Tract Bahar Fata¹, Danielle Gottlieb², Aaron Cois¹, George Stetten¹, John Mayer², Michael Sacks¹, ¹University of Pittsburgh, United States,²Children's Hospital Boston, United States
C23	Integrative capacity and functional competence of detergent-decellularized xenogeneic pulmonary valves Artur Lichtenberg¹, Igor Tudorache², Serghei Cebotari², Marc Suprunov¹, Payam Akhyari¹, Greta Tudorache², Axel Haverich², Andres Hilfiker², ¹Dep. of Cardiac Surgery, Germany,²Dep. of Cardiothoracic, Transplantation and Vascular Surgery, Medical School Hannover, Germany
C24	Functional Performance Of Decellularized Human Heart Valves Steven Walsh¹, Gregory Ray¹, Albert Heacox¹, ¹CryoLife, Incorporated, United States
C25	Growth factor modulation of extracellular matrix gene expression in aortic valve tissue engineering Andrew Appleton¹, Tom Appleton¹, Derek Boughner¹, Kem Rogers¹, ¹The University of Western Ontario, Canada
C26	Spontaneous Cell Repopulation of Valved Aortic Conduits after Decellularization and Allogeneic Transplantation Maurizio Marchini¹, Fulvia Ortolani¹, Antonella Bonetti¹, Alessandro Gandaglia², Filippo Naso², Michele Spina², Roberto Busetto², Ilaria Iacopetti², Luca Bellini², Silvia Tramarin², Roberto Bianco², Gino Gerosa², ¹University of Udine, Italy,²University of Padova, Italy
C27	Matrix-Dependent Adhesion of Vascular and Valvular Endothelial Cells in Microfluidic Channels Edmond Young¹, Aaron Wheeler¹, Craig Simmons¹, ¹University of Toronto, Canada
C28	Interaction between Mesenchymal Stem Cells and the Extracellular Matrix; Relevance to Tissue Engineering Heart Valves Sally A Dreger¹, Patricia M Taylor¹, Magdi H Yacoub¹, Adrian H Chester¹, ¹Imperial College London, Heart Science Centre, United Kingdom
C29	Synthetic Peptides for Heart Valve Tissue Engineering: Smooth Muscle Cells Adhesion Tests Rocio Huerta-Cantillo¹, Alessandro Gandaglia¹, Michele Spina¹, Gino Gerosa¹, Monica Dettin¹, ¹University of Padova, Italy
C30	Alternate to collagen: Synthesis of artificial collagen gels based on polymerisable collagen-mimetic peptides Murugesan Muthu¹, Sanjiv Sharma¹, Cass Tony¹, Yacoub Magdi¹, ¹Imperial College, United Kingdom
C31	Living, Autologous Tissue-engineered Heart Valves for Minimally Invasive Replacement Procedures Petra Dijkman¹, Anita Mol¹, Doerthe Schmidt², Rene Stenger², Jeroen Kortsmit¹, Gregor Zund², Frank Baaijens¹, Hoerstrup Simon², ¹Department of Biomedical Engineering, Eindhoven University of Technology, Netherlands,²Clinic for Cardiovascular Surgery and Department of Surgical Research, University Hospital, Switzerland
C32	Percutaneous aortic valve replacement: Laser-assisted Resection of the Aortic Valve using a Transapical Approach René Quaden¹, Tim Attmann¹, Michael Schünke³, Lucian Lozonschi⁴, Dirk Theisen-Kunde⁵, Jochen Cremer¹, Georg Lutter¹, ¹University Hospital of Schleswig-Holstein, Germany,²Institute for Microtechnology IMT, University of Braunschweig, Germany,³Institute of Anatomy, Christian-Albrechts-University of Kiel, Germany,⁴School of Medicine and Public Health, University of Wisconsin, Division of Cardiac Surgery, United States,⁵Institute of Biomedical Optics, University of Luebeck, Germany
C33	Transapical Mitral Valved Stent Implantation Lucian Lozonschi¹, Rene Quaden², Dolores Snell¹, Satoru Osaki¹, Jian Hu¹, Niloo Edwards¹, Georg Lutter², ¹Deparment of Cardiothoracic Surgery, University of Wisconsin School of Medicine, United States,²Department of Cardiovascular Surgery, University Hospital Schleswig-Holstein, Germany
C34	Etiology of Patient-prosthesis mismatch in aortic valve surgery Mano Thubrikar¹, Mahua Ghosh², Brett Fowler³, Robert Gordon⁴, Francis Robicsek³, ¹South Dakota School of Mines & Technology, United States,²University of Saskatchewan, Canada,³Heineman Medical Research Laboratory, United States,⁴Heart Doctors, United States
C35	Comparison Of Long Term Results Of Implantation Small Size Biological Stentless, Stented And Mechanical Prostheses In Aortic Position Tomasz Niklewski¹, Jerzy Foremny¹, Tomasz Kukulski¹, Dariusz Puszczewicz¹, Roman Przybylski¹, ¹Silesian Center For Heart Diseases, Poland
C36	Factors influencing the oxygen consumption rate of aortic valve interstitial cells (VICs): application to tissue engineering Ling Wang¹, Stacy-Paul Wilshaw¹, Sotirios Korossis¹, John Fisher¹, Zhongmin Jin¹, Eileen Ingham¹, ¹Institute of Medical and Biological Engineering, United Kingdom
C37	Molecular Mechanisms of Endothelial Progenitor Cell Attachment and Retention on Cholesterol Modified Polyurethane Heart Valve Leaflets Stanley Stachelek¹, Masako Ueda¹, Ivan Alferiev¹, Robert Levy¹, ¹Children's Hospital of Philadelphia, United States
C38	Nano-Technology and Tissue-Engineering for Self-Seeding Biological Glutardialdehyde-Fixed Heart Valve Prostheses Norbert W. Guldner¹, Markus Heinlein², Inka Jasmund¹, Veronika Meier¹, Florian Flüß¹, Andeas Gebert³, Daniel Rode¹, Ralf Noel³, Hans-H. Sievers¹, ¹University Hospital Schleswig-Holstein, Germany,²GfE Medizintechnik, Germany,³University of Lübeck, Germany
C39	Myocardial Tissue Engineering: The in vitro generation of a vascularized 3D matrix Antonia Bär¹, Philipp Fischer¹, Axel Haverich¹, Andres Hilfiker¹, ¹MHH, Germany

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